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KMID : 0361520110220020089
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Korean Journal of Psychopharmacology
2011 Volume.22 No. 2 p.89 ~ p.95
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Smoking Behavior and Loudness Dependence of the Auditory Evoked Potential among Male Patients with Major Depressive Disorder
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Yang Eun-Kyoung
Kim Jin-Hwan
Lee Seung-Hwan
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Abstract
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Objective: The loudness dependence of the auditory evoked potential (LDAEP) has been known as an indicator of central serotonergic neurotransmission. Nicotine increases the release of serotonin levels. The current study investigated whether cigarette smoking would make difference in LDAEP among male patients with major depressive disorder.
Methods: Twenty-four non-smoking and 20 smoking male patients meeting DSM-IV criteria for major depressive disorder (MDD) were recruited. There was no significant difference in severity of MDD symptoms between the two groups. The age of participants ranged from 20 to 65 years old. Event-related potentials (ERP) N100 were measured on 5 different sounds (55, 65, 75, 85, 95 dB) and on 5 electrodes (Fz, Cz, Pz, C5, C6). The N1/P2 peak to peak amplitudes and amplitude slope according to 5 different sounds were calculated.
Results: LDAEP was significantly weaker in the smoking group in comparison to the non-smoking group (p<0.05). Among non-smoking group LDAEP was negatively correlated with a core depression subscale of Hamilton Rating Scale for Depression (HAM-D) (r=-0.41, p<0.05).
Conclusion: LDAEP of the smoking patients with MDD group was weaker than the non-smoking patient with MDD group’s. This result suggests that smoking may have increased the release of serotonergic neurotransmission in patients with MDD. Future studies need to examine LDAEP changes before and after tobacco use among smoking patients.
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KEYWORD
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Nicotine, Serotonin (5-HT), Loudness dependence of the auditory evoked potential, Major depressive disorder
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